If packing suitcases for anything longer than a 4-day trip:
pack outfits or clothes of one type in mesh bags or use Zip-locks or simlar resealable bags.
For kids, pack whole outfits in a bag (top, bottom, underclothes/diaper, socks, accessories). Depending on the size of the bag and the season (summer clothes are smaller), you may be able to fit 2, 3, or more outfits rolled up separately in a bag. Remember, plastic bags can be a suffocation hazzard! Mesh bags are safer for kids.
For adults, if you use plastic bags (cheaper and easier to see contents, though not as cool) you’ll need at least 1-gallon sized bags, but 2-gallon bags can be even more useful. Pack all your undershirts in one. All your socks in another. Etc.
Later when you are searching for things, you can pull out a bag, get what you need, and put it back in the suitcase without having to reorganize everything.